Browsing Experimentally Confirmed database

Result: Your query found 27 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
actA
  • BacMet ID: BAC0567
  • Code for: Enzyme
  • Family: CN hydrolase family. Apolipoprotein N-acyltransferase subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti TG2-6
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid]
  • Description: Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti.
  • Length (amino acid): 531
  • Reference: Tiwari et al. 1996; Pubmed- 8868435, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actR
  • BacMet ID: BAC0565
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 194
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actS
  • BacMet ID: BAC0566
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 433
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    asr
  • BacMet ID: BAC0038
  • Code for: Unknown
  • Family: asr family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid shock protein Asr; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0).
  • Length (amino acid): 102
  • Reference: Seputiene et al. 2003; Pubmed- 12670971

    		• Similar resistance genes in 'BacMet Predicted database'
    eefA
  • BacMet ID: BAC0494
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: A periplasmic intermediate, EefA. Part of the EefXABC operon. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 374
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

    		• Similar resistance genes in 'BacMet Predicted database'
    eefX
  • BacMet ID: BAC0495
  • Code for: Unknown
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Part of eefXABC operon in K. pneumoniae. This gene is absent in the similar efflux system eefABC in other bacteria (such as Enterobacter aerogenes). Comaparative study suggests that it could be a regulator of the EefABC tripartite efflux system. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 61
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

    		• Similar resistance genes in 'BacMet Predicted database'
    gadA
  • BacMet ID: BAC0172
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

    		• Similar resistance genes in 'BacMet Predicted database'
    gadB
  • BacMet ID: BAC0173
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

    		• Similar resistance genes in 'BacMet Predicted database'
    gadC/xasA
  • BacMet ID: BAC0174
  • Code for: Enzyme
  • Family: Amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: GadC functions as a transporter for the product of glutamate decarboxylase, g-aminobutyrate
  • Length (amino acid): 511
  • Reference: Hersh et al. 1996; Pubmed- 8682809, Waterman et al. 1996; Pubmed- 8885264

    		• Similar resistance genes in 'BacMet Predicted database'
    gadE/yhiE
  • BacMet ID: BAC0175
  • Code for: Regulator
  • Family: Contains 1 HTH luxR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci.
  • Length (amino acid): 175
  • Reference: Ma et al. 2003; Pubmed- 12940989, Hommais et al. 2004; Pubmed- 14702398

    		• Similar resistance genes in 'BacMet Predicted database'
    gadW/yhiW
  • BacMet ID: BAC0176
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters.
  • Length (amino acid): 242
  • Reference: Ma et al. 2002; Pubmed- 12446650

    		• Similar resistance genes in 'BacMet Predicted database'
    gadX
  • BacMet ID: BAC0177
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Role in acid resistance, increases multidrug resistance in E. coli by activating the MdtEF multidrug efflux pump; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. It can confer resistance to antibiotics such as oxacillin, cloxacillin, nafcillin, erythromycin etc.
  • Length (amino acid): 274
  • Reference: Nishino et al. 2008; Pubmed- 18297445, Shin et al. 2001; Pubmed- 11555293

    		• Similar resistance genes in 'BacMet Predicted database'
    hdeA/yhiB
  • BacMet ID: BAC0185
  • Code for: Chaperone
  • Family: HdeA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeA; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 110
  • Reference: Hong et al. 2005; Pubmed- 15911614

    		• Similar resistance genes in 'BacMet Predicted database'
    hdeB/yhiC
  • BacMet ID: BAC0186
  • Code for: Chaperone
  • Family: HdeB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeB; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.
  • Length (amino acid): 108
  • Reference: Kern et al. 2007; Pubmed- 17085547

    		• Similar resistance genes in 'BacMet Predicted database'
    hefA
  • BacMet ID: BAC0187
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer-membrane protein of the HefABC efflux system HefA; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 477
  • Reference: Liu et al. 2008; Pubmed- 18777600

    		• Similar resistance genes in 'BacMet Predicted database'
    hefC
  • BacMet ID: BAC0188
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Cytoplasmic pump protein of the HefABC efflux system HefC
  • Length (amino acid): 1028
  • Reference: Kutschke et al. 2005; Pubmed- 15980386

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0569
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 129
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0190
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae), Plasmid pSymA (Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti))
  • Location: Plasmid pSMED01
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 147
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtB/yegN
  • BacMet ID: BAC0211
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Hydrochloric acid (HCl) [class: Acid]
  • Description: Multidrug resistance protein MdtB; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
  • Length (amino acid): 1040
  • Reference: Deininger et al. 2011; Pubmed- 21541325

    		• Similar resistance genes in 'BacMet Predicted database'
    PA0320
  • BacMet ID: BAC0297
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species
  • Length (amino acid): 116
  • Reference: Fukushima et al. 2012; Pubmed- 22990488

    		• Similar resistance genes in 'BacMet Predicted database'
    rpoS
  • BacMet ID: BAC0335
  • Code for: Regulator
  • Family: sigma-70 factor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli, Shigella flexneri
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Sodium hydroxide (NaOH) [class: Base]
  • Description: RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RpoS is required for optimal maintenance of pH homeostasis of stationary phase cells exposed to extreme acid.
  • Length (amino acid): 330
  • Reference: Small et al. 1994; Pubmed- 8132468

    		• Similar resistance genes in 'BacMet Predicted database'
    ydeO
  • BacMet ID: BAC0437
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: HTH-type transcriptional regulator YdeO; Induces the Expression of gadE and mdtEF. Could also regulate the Expression of other genes involved in acid resistance
  • Length (amino acid): 253
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Nishino et al. 2009; Pubmed- 19329985, Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    ydeP
  • BacMet ID: BAC0438
  • Code for: Enzyme
  • Family: Prokaryotic molybdopterin-containing oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid resistance protein YdeP; Involved in acid resistance
  • Length (amino acid): 759
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    yhcN
  • BacMet ID: BAC0446
  • Code for: Unknown
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer membrane protein YhcN; stress response protein
  • Length (amino acid): 87
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yjaA
  • BacMet ID: BAC0447
  • Code for: Unknown
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress response protein YjaA; a YjaA mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 127
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    ymgB/ariR
  • BacMet ID: BAC0450
  • Code for: Binding protein
  • Family: AriR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Hydrochloric Acid (HCl) [class: Acid], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Two-component-system connector protein YmgB/AriR; a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H2O2. Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; YmgB probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein. Deletion increases biofilm formation.
  • Length (amino acid): 88
  • Reference: Lee et al. 2007; Pubmed- 17765265

    		• Similar resistance genes in 'BacMet Predicted database'
    yodD
  • BacMet ID: BAC0451
  • Code for: Unknown
  • Family: Contains a DUF2525 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress protein YodD; a yodD mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 75
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
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